Hedgehog (HH) signaling is important for embryonic pattering and stem cell differentiation.The G protein-coupled Dual Inlet 5 Way Water Valve receptor (GPCR) Smoothened (SMO) is the key HH signal transducer modulating both transcription-dependent and transcription-independent responses.We show that SMO protects naive mouse embryonic stem cells (ESC
The cultural practices encompassing etiquette and customs, along with their associated spaces, play a crucial role in preserving traditional Chinese culture.However, these cultural elements are currently under significant and irreversible threats, necessitating the strengthening of relevant theories and case studies for their safeguarding.In light
It is becoming obvious that the abundance of Clogs microplastics is increasing in worldwide oceans, raising concerns about their impact on marine ecosystems.Tiny plastic particles enter the body of marine organisms not only via oral ingestion but also through the body surface (e.g., gills or epidermis), but the mechanism of internalization into cel
Osteoarthritis (OA) is the most common articular disease world wide.It is the result of both mechanical and biological events that destabilize the normal coupling of degeneration synthesis of articular cartilage and subchondral bone.Rheumatologist often routinely order tests for rheumatoid factor and erythrocyte sedimentation rate (ESR) for all pat